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| Antibody (Name) | Company | IgM Source | Antigen | Indication | Most Advanced Clinical Development |
|---|---|---|---|---|---|
| Campath-1M | Academic (MRC-RDCT) |
Rat | CD52 | Graft vs. host disease | Phase 2 |
| E5 (Xomen-E5) | XOMA | Mouse | J5 lipid A | Sepsis | Phase 3 |
| HA-1A (Centoxin) | Centocor | Human | J5 lipid A | Sepsis | Phase 3 |
| Fanolesomab-Tc99 (NeutroSpec) |
Palatine | Mouse | CD15 | Appendicitis | Phase 3 |
| IgM cocktail (5) | Cutter/Miles | Human | LPS | Sepsis | Phase 1 |
| Mab 16.88 | Academic (Free University Hospital) |
Human | Colon cancer antigen |
Colorectal cancer | Phase 1 |
| MAB-T88 | Chiron | Human | LPS | Neutropenia | Phase 1 |
| PAT-SC1 | Partridge | Human | CD55 isoform |
Gastric cancer | Phase 1 |
| ABX-CBL | Abgenix | Mouse | CD147 | Graft vs. host disease |
Phase 2/3 |
| L612 | Chugai | Human | Ganglioside GM3 |
Melanoma | Phase 1 |
| MORAb-028 | Morphotek/Eisai | Human | Ganglioside GD2 |
Melanoma | Phase 1 |
| AR-101 | Aridis | Human | LPS | Nosocomial P. a. pneumonia |
Phase 2a |
| mAb216 | Academic (Stanford) |
Human | CDIM | B-lineage ALL | Phase 1 |
| PAT-SM6 | Partridge | Human | GRP78 | Multiple myeloma | Phase 1/2a |
| ARG098 | Argenes | Mouse/Human (chimeric) |
FAS | Rheumatoid arthritis |
Phase 1/2 |
| rHIgM22 | Grant | Human | CNS myelin | Multiple sclerosis/neuronal degeneration |
Phase 1 |
| TOL101 | Tolerates | Mouse | ab TCR | Renal transplant | Phase 2 |
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Keyt BA, Baliga R, Sinclair AM, et al. Structure, Function, and Therapeutic Use of IgM Antibodies. Antibodies[J], 2020, 9(4): 53. doi:10.3390/antib9040053
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