¿¹Ì寬¶ÎFab

ʲôÊÇFab£¿

FabƬ¶Î£¨Fragment of antigen binding£©Ò²½Ð×ö¿¹Ô­½áºÏƬ¶Î£¬ÊÇ¿¹Ìå½á¹¹ÖпÉÒÔÓ뿹ԭ½áºÏµÄÇøÓò¡£FabƬ¶ÎÓÉÒ»ÌõÍêÕûµÄÇáÁ´ÓëÖØÁ´µÄVHºÍCH1½á¹¹Óò£¨Fd¶Î£©×é³É£¬·Ö×ÓÁ¿Ô¼5¡Á104¡£ÇáÁ´ÓëÖØÁ´¾ù´æÔÚÒ»¸öºã¶¨ÇøÓëÒ»¸ö¿É±äÇø£¬ÇáÖØÁ´¼ä´æÔÚ¶þÁò¼üÁ´½Ó¡£
Ŀǰ£¬Fab¿¹Ì寬¶Î¿ÉÒÔÔÚʵÑéÊÒÖÆ±¸³öÀ´¡£ÔÚľ¹Ïµ°°×øµÄ×÷ÓÃÏ£¬ÈËÃâÒßÇòµ°°×G£¨Immunoglobulin G£¬IgG£©¿ÉÒÔ±»½µ½âΪÁ½¸öFabƬ¶Î¼°Ò»¸öFcƬ¶Î£¨fragment crystallized, ½á¾§Æ¬¶Î£©£»ÔÚθµ°°×øµÄ¶î×÷ÓÃÏ£¬IgG¿ÉÒÔ±»½µ½âΪһ¸öF(ab¡¯)2Ƭ¶ÎºÍÒ»¸öpFc¡¯Æ¬¶Î¡£F(ab¡¯)2Ƭ¶Î¿ÉÒÔ½øÒ»²½±»»¹Ô­£¬ÐγÉÁ½¸öFab¡¯Æ¬¶Î¡£

Fab ¿¹Ìå½á¹¹

ø½â·¨ÖƱ¸Fab¡¢Fab¡¯ÒÔ¼°F(ab¡¯)2

FabƬ¶ÎÖÆ±¸

ĿǰÓÐø½â·¨¡¢ÀûÓñí´ïÏµÍ³ÖÆ±¸ÒÔ¼°ÀûÓÃÊɾúÌåչʾ¼¼Êõ½øÐп¹Ìå¿âɸѡµÈ·½·¨½øÐÐFabƬ¶ÎµÄÖÆ±¸¡£Ã¸½â·¨Í¨³£ÓÃľ¹Ïµ°°×ø»òθµ°°×øµÈø¶ÔÈËÃâÒßÇòµ°°×G½øÐнµ½â£¬µÃµ½F(ab¡¯)2£¬Fab£¬FcƬ¶ÎµÈ²úÎÀûÓñí´ïϵͳÉú²úFabƬ¶Î£¬Í¨³£ÀûÓô󳦸˾ú±í´ïϵͳÓ벸È鶯Îï±í´ïϵͳ¡£´ó³¦¸Ë¾ú±í´ïϵͳ¾ßÓÐÉú²ú³É±¾µÍ¡¢Éú²úËÙ¶È¿ìµÈÓŵ㣬µ«ÈÝÒ×Ðγɰüº­Ì壬¸´ÐÔºó»îÐÔÄѱ£Ö¤£¬ÓпÉÄÜ»áÓ°ÏìʵÑéÑо¿¡£Óò¸È鶯Îïϵͳ±í´ïFab¿¹Ì寬¶Î£¬¿ÉÒÔ˳ÀûµÄÐγɶþÁò¼ü£¬¸ü½Ó½üÌìÈ»Fab½á¹¹£¬»îÐÔÒ²¸ü¸ß£¬¿ÉÒÔ¸üºÃµÄÓ¦ÓÃÓÚÏÂÓοÆÑÐÑо¿£¬ÊÇÓÅÓڴ󳦸˾ú±í´ïϵͳµÄÑ¡Ôñ¡£ÀûÓÃÊɾúÌåչʾ¼¼Êõ£¬ÏÈÖÆ±¸FabƬ¶Î¿¹Ìå¿â£¬ÔÚ¾­¹ýÊýÂÖµÄɸѡ¸»¼¯£¬¼´¿ÉµÃµ½¸ßÇ׺ÍÐÔµÄFab¿¹Ìå¡£

Fab¿¹Ì寬¶ÎµÄ´¿»¯

¶ÔIgG½øÐÐø½âºó£¬¿ÉÒԵõ½FabƬ¶ÎÓëFcƬ¶ÎµÄ»ìºÏÎï¡£¿ÉÓÃprotein A¶Ô»ìºÏÎï½øÐд¿»¯£¬µ°°×A¿ÉÒԺͻìºÏÎïÖеÄFc¶ÎÌØÒìÐÔ½áºÏ£¬×îÖÕ±»Ï´ÍÑ£¬´Ó¶ø´ïµ½´¿»¯µÄÄ¿µÄ¡£

ÔÚ±í´ïϵͳ±í´ï³öFabƬ¶Îºó£¬¿ÉÒÔÔÚ·Ö×ÓµÄC¶Ë¼Ó6¸öHis±êÇ©£¬ÓÃÇ׺ͲãÎö¼¼Êõ¶Ô±í´ïºóµÄ²úÎï½øÐд¿»¯¡£

FabƬ¶ÎµÄ·¢Õ¹ÓëÓ¦ÓÃ

ºÍµ¥¿¹µÄ·¢Õ¹Àú³ÌÒ»Ñù£¬FabµÄ·¢Õ¹¾­ÀúÁËÊóÔ´ÐÔ£¨murine£©¡¢Ç¶ºÏÐÔ£¨chimeric£©¡¢ÈËÔ´»¯£¨humanized£©ºÍÈ«ÈËÔ´µ¥¿¹ÐÔ£¨human monoclonal antibody£©Ëĸö½×¶Î¡£Ç¶ºÏFabƬ¶ÎÊÇÓÉÊóÔ´¿É±äÇøºÍÈËÔ´ºã¶¨Çø×é³É£¬ÈËÔ´»¯FabƬ¶ÎÊÇÓÉÊóÔ´CDRºÍÈËÔ´¿ò¼ÜÇø×é³É¡£

ÓëÍêÕûµÄIgGÏà±È£¬FabƬ¶ÎȱÉÙFc¶Î£¬ËäÈ»ÄÜÓ뿹ԭѡÔñÐÔ½áºÏµ«²»»á·¢Éú³Áµí·´Ó¦£»ÓÉÓÚ×ÔÉíÃâÒßÔ­ÐԵͣ¬²»Äܱ»»îÌåµÄÃâÒßϸ°ûʶ±ð£¬Òò´ËÄÜÏÔÖø½µµÍ³¬ÃôÐÔ·´Ó¦·¢ÉúµÄ¸ÅÂÊ£¬Ìá¸ß²úÆ·µÄ°²È«ÐÔ¡£FabÀ࿹Ì寬¶Î¾ßÓзÖ×ÓÖÊÁ¿Ð¡¡¢×éÖ¯·Ö²¼ÌØÒìÐÔÇ¿¡¢ÃâÒßÔ­Ð͵Í¡¢¿É»ùÒò¹¤³Ì²Ù×÷µÈÌØµã£¬Ê¹Fab³ÉΪÁËÒ½Ò©Ñо¿ÁìÓòµÄÖØÒª³ÉÔ±Ö®Ò»£¬FabÀàÒ©ÎïÔÚÔ¤·À¡¢Õï¶Ï¡¢ÖÎÁƵÈÁìÓòÓÐ׏㷺µÄÓ¦Óá£

Ïà¹Ø·þÎñ

Ïà¹ØÔĶÁ

Á¢¼´Ñ¯¼Û
  • ÐÕÃû

  • µ¥Î»

  • µç»°

  • ×ÉѯÏîÄ¿

  • ÑéÖ¤Âë

  • ÁôÑÔ:

¡¾ÍøÕ¾µØÍ¼¡¿¡¾sitemap¡¿
¡¾ÍøÕ¾µØÍ¼¡¿¡¾sitemap¡¿